Lost Universe 

Kane Blueriver and Canal, his AI companion, are trouble contractors who take jobs which require their special skills. This could go from armed escort, to patrol, to capturing dangerous criminals. Milly is a private eye who has to be the best at everything (uchuu ichi!!). When the three of them get together, they run into one mess after another, gradually uncovering more of a mystery that ties the legendary Lost Ships to all of their pasts, bringing them closer and closer to a discovery that something called Nightmare would rather not have them find...